KEY EVIDENCE

The Library provide website evidence for key issues contained in my blogs. The evidence is key research reports. Click on the website URL for your mental exercise. Many reports are abstract only. I will continue to add additional research reports as appropriate.

REF #, DATE – AUTHOR ISSUE ARTICLE LINK
Ref. #1 – Mar, 1991 –
Braak & Braak
Staging Neuron Damagehttps://www.ncbi.nlm.nih.gov/pubmed/1759558
Ref. #2 – July 1996 –
Teresa Gomez-Isla
Quantifying neuon damagehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6578866/
Ref. #3 – Jan 2011 –
TE Golde et. al.
Shift to Presymptomatic ADhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058906/
Ref. # 4 – Aug. 2016 –
Reisa A. Sperling et. al.
Prevent Amyloid Aggregationhttps://projectreporter.nih.gov/project_info_description.cfm?aid=9194290
Ref. #5 – Jan. 2018 Rand Rpt.
Jakub P. Hlavka et. al.
Future Dementia staff shortageshttps://www.rand.org/pubs/research_reports/RR2503.html
Ref. #6 – Feb. 2018 FDAPresymptomatic Guidancehttps://www.fda.gov/media/110903/download
Ref. #7 – April 2018 – NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease. Clifford R Jack Jr. et. al. Biological Biomarmers Framework for Presymptomatic AD https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958625/
Ref. #8 – Mar, 2003
Tangles and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s Disease.
Gamakopoulos P et.al.




https://www.alzforum.org/news/research-news/can-apoe-mutation-halt-alzheimers-diseaseAmyloidvolume has no additional preictive value , in terms of clincopathlogic correlations, beyond its interaction with Neurofibrilary tangles (NFT)https://www.ncbi.nlm.nih.gov/pubmed/12743238
Ref. #9: – Nov. 2019 –> esistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report. Arboleda-Velasquez JF et. al.
Alzforum”s –> Can an ApoE Mutation Halt Alzheimer’s Disease? https://www.alzforum.org/news/research-news/can-apoe-mutation-halt-alzheimers-disease
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