• Bruce’s Hypothesizes Alzheimer’s is a biological disease of the Brain.
  • Currently, there is no cure, no approved drug or vaccine for effective treatment, delay, or prevention.
  • AD begins when amyloid triggers Tau fibrils and tangles that cause neuron loss.
  • Once Tau fibrils & tangles cause neuron loss, AD progresses without amyloid.
  • Clinical Trials continue to target the wrong stage for amyloid to be effective. Once Tau fibrils & tangles cause neuron loss, AD progresses without amyloid.
  • Interventions to delay Tau’s fibrils & tangles and Tau’s progression of neuron loss will take many years because of Tau protein complexity.
  • Without available treatment, AD has been in research for the past four decades.
  • Issues include: a) the complexity of the brain; b) lost brain neuron that can’t be regenerated; c) insufficient biological biomarker tools; d) FDA’s meaningful cognitive benefit” requirement .
  • Symptomatic AD patients can manage a normal lifestyle until Activity of Daily Living (ADL) is no longer independently sustainable & AD becomes a Dementia syndrome.
  • Dementia is the image of mental disorders & a caregiver’s nightmare.
  • Stakeholders are patients, caregivers, government, pharmaceuticals, medical professionals, academia, institutional care personal, advocate organizations, and legal specialist.

Help Others by Leaving a Reply

%d bloggers like this: